In situ programming of intratumoural stem cell-like memory CD8+ T cells enables durable antitumour immunity in immunosuppressive tumours
Xiaomeng Wang, Ana Vitlić, Erminia Romano, Rachel Scholey, Leo A. H. Zeef, Conrado Guerrero Quiles, Antonia Banyard, Richard C. Walshaw, Tim Illidge, Jamie Honeychurch
This study shows that activating pattern recognition receptors in tumors enhances stem cell-like memory CD8 T cells, improving antitumor immunity when combined with radiation in lung and bladder cancer models.
bioRxiv · Feb 7, 2026 · PreprintCancer Biology