Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiency
Ali Abdelfattah, Ahmad Habib, Leigh-anne Thomas, Juan Bautista Menendez-Gonzalez, Alhomidi Almotiri, Hind Alqahtani, Hannah Lawson, Sarab Taha, Millie Steadman, Radhika Athalye, Alex Gibbs, Hamed Alzahrani, Ali Alshahrani, Alice Cato, Peter J. Giles, , Neil P. Rodrigues
This study identifies how Gata2 haploinsufficiency disrupts HSC function and drives pre-leukemic changes through DNA damage and inflammatory signaling, with ASXL1 mutations exacerbating these defects.
Stem Cell Reports · Jul 31, 2025Peer-reviewedCancer Biology