Rafael Vázquez‐Torres

This study shows that carbonic anhydrase inhibitors improve heart function in Alzheimer's mice by reducing amyloid-β and restoring neurotrophic signaling.

This study shows that inhibiting mitochondrial carbonic anhydrase-VB protects brain endothelial cells and improves memory in Alzheimer's disease models.

This study identifies Aβ-induced cardiac neurotrophic signaling impairment in AD models and human tissue, linking AD pathology to cardiac dysfunction.

This study shows that homocysteine exacerbates amyloid β-induced cerebral endothelial cell apoptosis, BBB dysfunction, and angiogenic impairment through shared molecular mechanisms.

This study tests FDA-approved carbonic anhydrase inhibitors in a transgenic AD model, finding they reduce amyloid beta pathology and improve cognition by enhancing cerebrovascular health and glial function.