Elisa Canepa

This study shows that inhibiting mitochondrial carbonic anhydrase-VB protects brain endothelial cells and improves memory in Alzheimer's disease models.

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

This study shows that homocysteine exacerbates amyloid β-induced cerebral endothelial cell apoptosis, BBB dysfunction, and angiogenic impairment through shared molecular mechanisms.

This study tests FDA-approved carbonic anhydrase inhibitors in a transgenic AD model, finding they reduce amyloid beta pathology and improve cognition by enhancing cerebrovascular health and glial function.