hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function
Homa Majd, Ryan M. Samuel, Jonathan T. Ramirez, Ali Kalantari, Kevin Barber, Zaniar Ghazizadeh, Angeline K Chemel, Andrius Cesiulis, Mikayla N Richter, Subhamoy Das, Matthew G. Keefe, Jeffrey Wang, Rahul K Shiv, Conor J. McCann, Samyukta Bhat, , Faranak Fattahi
This study develops hPSC-derived enteric ganglioids to model human ENS development and function, identifying drug candidates and PDGFR inhibition as key factors in NO neuron specification.
bioRxiv · Jan 4, 2022 · PreprintDevelopmental Biology