Ryan M. Samuel

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

The paper highlights the need for a unified multimodal approach to define cellular identity in the enteric nervous system using transcriptomic and other omics data.

The paper shows that lineage origins shape gene regulation and function in V2a neurons, identifying key regulators specific to posterior identities.

The paper generates melanocytes from hPSCs through two distinct developmental trajectories and identifies T2-specific factors that promote melanoma metastasis.

This study develops hPSC-derived enteric ganglioids to model human ENS development and function, identifying drug candidates and PDGFR inhibition as key factors in NO neuron specification.