Conor J. McCann

This study demonstrates that transplanting human pluripotent stem cell-derived enteric nervous system progenitors can improve contractile function and rescue molecular pathways in Hirschsprung disease colonic tissue.

The paper investigates the emergence of coordinated intestinal motility in human fetal development, identifying calcium dynamics and purinergic signaling as key drivers.

The paper establishes a humanized neuronal model to investigate the effects of manganese dysregulation on neuronal function and disease mechanisms.

This study develops hPSC-derived enteric ganglioids to model human ENS development and function, identifying drug candidates and PDGFR inhibition as key factors in NO neuron specification.

This study investigates the role of TALPID3/KIAA0586 in gastrointestinal development across species, showing its impact on tissue patterning and neural crest cell behavior.

This study shows retinoic acid accelerates the generation of enteric neural progenitors from human pluripotent stem cells, which can form enteric neurons and colonize the ENS in mice.