Faranak Fattahi

Age-associated Autoimmunity Driven by T cell Immunosenescence

This study identifies age-associated senescent CD4+ T cells as drivers of autoimmunity in CIDP, showing that senolytic and senomorphic therapies can mitigate disease.

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures

This paper develops a platform for longitudinal imaging and transcriptomics of live cells, revealing adaptive drug-resistant states and key drivers of cellular function through integrated analysis.

ENS lineage potential is not intrinsically regionalized but is modulated by PTPRZ1 signaling

The paper shows the enteric nervous system (ENS) lacks intrinsic regionalization but is shaped by PTPRZ1 signaling from the gut microenvironment during development.

Comparative analysis of human and mouse ovaries across age

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

A call for a unified and multimodal definition of cellular identity in the enteric nervous system

The paper highlights the need for a unified multimodal approach to define cellular identity in the enteric nervous system using transcriptomic and other omics data.

High-Throughput Screening on Primary Tumor-Associated Microglia and Macrophages Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Partners for Immunotherapy in Glioblastoma

This study identifies HDAC inhibitors as enhancers of TAM phagocytosis and synergistic partners for immunotherapy in GBM through high-throughput screening.

Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons

The paper shows that lineage origins shape gene regulation and function in V2a neurons, identifying key regulators specific to posterior identities.

Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy

This study derives Schwann cells from human pluripotent stem cells to model diabetic peripheral neuropathy and identify a drug candidate that rescues sensory function and prevents myelin damage.

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma

The paper generates melanocytes from hPSCs through two distinct developmental trajectories and identifies T2-specific factors that promote melanoma metastasis.

hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function

This study develops hPSC-derived enteric ganglioids to model human ENS development and function, identifying drug candidates and PDGFR inhibition as key factors in NO neuron specification.