Antagonism between bacteriophages and macrophages decreases efficacy of a phage cocktail and increases bacteriophage resistance
Meaghan Castledine, Zuzanna Szczutkowska, Andrew Matthews, Sarah K. Walsh, Rai Lewis, Suzanne Kay, Janet A. Willment, Gordon D. Brown, Angus G. J. Buckling
This study shows macrophages reduce bacteriophage efficacy and increase bacterial resistance in Pseudomonas aeruginosa during phage therapy.
bioRxiv · May 16, 2025 · PreprintEvolutionary Biology