Leveraging HIV-Specific CAR T Cells and Rapamycin Treatment in Kick-and-Kill HIV Cure Approaches
Nishad S. Maggirwar, Jose A. Moran, Wenli Mu, Thomas D. Zaikos, Tessa C. Chou, Shireen R. Turner, Brian H. Yu, Alok Ranjan, Rami Hourani, Paul A. Wender, Anjie Zhen, Matthew D. Marsden
This paper demonstrates that combining HIV-specific CAR T cells with rapamycin and latency reversing agents can reduce immune exhaustion and effectively target HIV-infected cells.
bioRxiv · Jan 15, 2026 · PreprintImmunology