Multivalent Lipid MVL5 Micellar Nanoparticles Exhibit Dramatically Increased Loading of Paclitaxel with PEGylation Enhancing Human Cancer Cell Penetration Depth and Cytotoxicity
William S. Fisher, Aria Ghasemizadeh, Sherwin Roshan, Anna Goldstein, Jessica Douglas, Ramon Perez, Youli Li, Kai K. Ewert, Cyrus R. Safinya
This study shows that MVL5-based micellar nanoparticles enhance paclitaxel solubility and cytotoxicity in cancer cells, with PEGylation improving cellular uptake and penetration.
bioRxiv · May 24, 2025 · PreprintBioengineering