Author

William S. Fisher

University of California, Santa BarbaraORCID 0000-0002-7493-1567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

Cyrus R. SafinyaiD· 3 shared Kai K. EwertiD· 3 shared Jessica Douglas· 2 shared Ramon Perez· 2 shared Sherwin Roshan· 2 shared Youli LiiD· 2 shared Anjali J. Jobanputra· 1 shared Anna Goldstein· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiophysics

Cyrus R. SafinyaORCID

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Author profile →

3 papers

Recent·Most cited

BioengineeringbioRxivPreprintMay 24, 2025

Multivalent Lipid MVL5 Micellar Nanoparticles Exhibit Dramatically Increased Loading of Paclitaxel with PEGylation Enhancing Human Cancer Cell Penetration Depth and Cytotoxicity

William S. Fisher, Aria Ghasemizadeh, Sherwin Roshan…·Cyrus R. Safinya

This study shows that MVL5-based micellar nanoparticles enhance paclitaxel solubility and cytotoxicity in cancer cells, with PEGylation improving cellular uptake and penetration.

DOI 10.1101/2025.05.24.655953

humanexperimental assay

𝕏 PostBluesky

BiophysicsLangmuirPeer-reviewedFeb 13, 2025

Acidic Conditions Promote Clustering of Cancer Cell Derived Extracellular Vesicles and Enhance their Fusion with Synthetic Liposomes

William S. Fisher, Jessica Douglas, Sherwin Roshan…·Cyrus R. Safinya

This paper demonstrates that acidic conditions enhance EV-liposome fusion without additional fusogens, supported by FRET and microscopy, and suggests implications for drug delivery.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky

BiophysicsLangmuirPeer-reviewedSep 28, 2024

Mixtures of Intrinsically Disordered Neuronal Protein Tau and Anionic Liposomes Reveal Distinct Anionic Liposome-Tau Complexes Coexisting with Tau Liquid-Liquid Phase Separated Coacervates

Christine K. Tchounwou, Anjali J. Jobanputra, Dylan Lasher…·Cyrus R. Safinya

This paper investigates the interactions between tau protein and anionic liposomes, revealing distinct complexes and phase-separated coacervates under varying ionic conditions.

4 citations

humanproteomics

𝕏 PostBluesky