Acidic Conditions Promote Clustering of Cancer Cell Derived Extracellular Vesicles and Enhance their Fusion with Synthetic Liposomes
William S. Fisher, Jessica Douglas, Sherwin Roshan, Ramon Perez, Sophia Wei, Logan Roberts, Kai K. Ewert, Cyrus R. Safinya
This paper demonstrates that acidic conditions enhance EV-liposome fusion without additional fusogens, supported by FRET and microscopy, and suggests implications for drug delivery.
Langmuir · Feb 13, 2025Peer-reviewedBiophysics