AML patient blasts exhibit polarization defect upon interaction with bone marrow stromal cells.
Khansa Saadallah, Benoît Vianay, Louise Bonnemay, Hélène Pasquer, Lois M. Kelly, Stéphanie Mathis, Cécile Culeux, Raphael Marie, Paul-Arthur Meslin, Sofiane Fodil, Paul Chaintreuil, Emeline Kerreneur, Arnaud Jacquel, Emmanuel Raffoux, Rémy Nizard, , Manuel Théry
This study shows AML blasts fail to polarize when interacting with healthy stromal cells, and AML-derived stromal cells impair polarization of healthy HSPCs and AML blasts.
EMBO Reports · Jun 11, 2025Peer-reviewedCancer Biology