Author

Paul Chaintreuil

InsermORCID 0000-0002-4845-7304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Arnaud JacqueliD· 2 shared Emeline KerreneuriD· 2 shared Adèle RivaultiD· 1 shared Benoît VianayiD· 1 shared Camille LobryiD· 1 shared Cécile Culeux· 1 shared Cécile Favreau· 1 shared Chloe Delaby· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Arnaud JacquelORCID

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2 papers

Recent·Most cited

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

Emeline Kerreneur, Paul Chaintreuil, Chloe Delaby, Sonia Boulakirba, Maxence Bourgoin, Morgane Fajolles, Cécile Favreau, Adèle Rivault, Juba Bennour, Nathalie M Droin, Jean‐François Peyron, Johanna Chiche, Thomas Cluzeau, Michael L. Loschi, Patrick Auberger, , Arnaud Jacquel

This study identifies cathepsin B as a novel upstream activator of non-apoptotic caspase-8, driving anti-inflammatory macrophage polarization and differentiation.

bioRxiv · Aug 22, 2025 · PreprintImmunology

AML patient blasts exhibit polarization defect upon interaction with bone marrow stromal cells.

Khansa Saadallah, Benoît Vianay, Louise Bonnemay, Hélène Pasquer, Lois M. Kelly, Stéphanie Mathis, Cécile Culeux, Raphael Marie, Paul-Arthur Meslin, Sofiane Fodil, Paul Chaintreuil, Emeline Kerreneur, Arnaud Jacquel, Emmanuel Raffoux, Rémy Nizard, , Manuel Théry

This study shows AML blasts fail to polarize when interacting with healthy stromal cells, and AML-derived stromal cells impair polarization of healthy HSPCs and AML blasts.

EMBO Reports · Jun 11, 2025Peer-reviewedCancer Biology