Manuel Théry

Uncoupling microtubule lifetime, stability and post-translational modifications.

The paper measures microtubule turnover and PTMs in mouse cells, finding that PTMs do not accumulate with age or correlate with stability.

Deciphering the nanoscale architecture of presynaptic actin using a micropatterned presynapse-on-glass model

The paper presents a presynapse-on-glass model to study presynaptic actin architecture, showing actin enrichment correlates with synaptic cycling activity and identifies actin nanostructures.

Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons

This study directly labels microtubule turnover in developing neurons, revealing in-lattice repair and stabilization patterns during axon formation.

Contractile forces direct the chiral swirling of minimal cell collectives

This study shows that contractile forces in endothelial cell pairs determine the direction and strength of chiral swirling in minimal cell collectives.

A multicellular actin star network underpins epithelial organization and connectivity

This study identifies a multicellular actin star network in adult murine intestinal epithelium that maintains tissue stability and organization through mechanical and structural mechanisms.

Fabrication of microcompartments with controlled size and shape for encapsulating active matter

The paper describes the fabrication of microwells for encapsulating active matter, enabling controlled studies of cytoskeleton dynamics and other cellular processes.

AML patient blasts exhibit polarization defect upon interaction with bone marrow stromal cells.

This study shows AML blasts fail to polarize when interacting with healthy stromal cells, and AML-derived stromal cells impair polarization of healthy HSPCs and AML blasts.

Centrosome positioning independently of microtubule-based forces

The paper shows centrosome positioning is driven by actomyosin contractile networks and cell shape remodeling, not microtubule-based forces.

Filament transport supports contractile steady states of actin networks.

This study shows that actin network contractile steady states can be sustained by filament transport rather than assembly/disassembly in an in vitro system.

Balancing limited resources in actin networks competition

This study investigates how actin networks coexist under resource competition by using a reconstituted system, showing that protein turnover enables coexistence but intense competition favors stronger networks.

Disentangling the contributions of stress fibres and the unbundled actin meshwork to the anisotropy of cortical tension in response to cell shape

This study quantifies how cell shape influences cortical tension anisotropy by separating contributions from bundled and unbundled actin structures.

Geometrical confinement guides Brachyury self-patterning in embryonic stem cells.

This study shows that geometric cues can direct the self-patterning of Brachyury-positive cells in embryonic stem cell aggregates without relying on morphogen gradients.