ImmunologybioRxivPreprint
HIV-1 derived replication intermediates/oligonucleotides induce a type I IFN-dependent immune suppression via STING activation that can be restored by targeting IFNARI
Cecilia Svanberg, Ravi Prasad Mukku, Özkan Besler…·Marie Larsson
This study shows HIV-1-derived oligonucleotides activate STING and type I IFN signaling in dendritic cells, leading to immune suppression that can be reversed by targeting IFNAR1 with Anifrolumab.
DOI 10.1101/2025.02.17.638698