Ovarian hormones mediate the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice
Briana K. Chen, Christina T. LaGamma, Xiaoming Xu, Shi‐Xian Deng, Rebecca A. Brachman, Raymond F. Suckow, Thomas B. Cooper, Donald W. Landry, Christine Ann Denny
This study shows that (R,S)-ketamine and (2R,6R)-hydroxynorketamine prevent stress-induced depressive-like behavior in female mice, with ovarian hormones mediating their efficacy.
bioRxiv · Jul 24, 2019 · PreprintNeuroscience