Donald W. Landry

This paper describes a non-retinoid RBP4 antagonist, AKR-XI-85, that reduces lipofuscin accumulation in a mouse model of Stargardt disease.

The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.

The paper designs and synthesizes new activators of the p300 histone acetyltransferase enzyme to treat neurodegenerative and cancer disorders.

This paper shows that m-tirofiban, a non-partial agonist of IIbβ3, effectively inhibits venous thrombosis without increasing bleeding in a mouse model.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

This study shows that (R,S)-ketamine and (2R,6R)-hydroxynorketamine prevent stress-induced depressive-like behavior in female mice, with ovarian hormones mediating their efficacy.