NeurosciencebioRxivPreprint
Ovarian hormones mediate the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice
Briana K. Chen, Christina T. LaGamma, Xiaoming Xu…·Christine Ann Denny
This study shows that (R,S)-ketamine and (2R,6R)-hydroxynorketamine prevent stress-induced depressive-like behavior in female mice, with ovarian hormones mediating their efficacy.
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