Author

Rea M. Lardelli

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Jens Lykke‐AnderseniD· 2 shared Tiantai MaiD· 2 shared C Chaillan Huntington· 1 shared Eric L. Van NostrandiD· 1 shared Erica XiongiD· 1 shared Zhuoyi SongiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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6 top collaborators · 12 mutual co-author links

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2 shared papersMolecular Biology

Jens Lykke‐AndersenORCID

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2 papers

Recent·Most cited

Multiple Quality Control Checkpoints Safeguard Small Nuclear RNA Biogenesis and Prevent Assembly of Aberrant Spliceosomes

Tiantai Ma, C Chaillan Huntington, Zhuoyi Song, Rea M. Lardelli, Eric L. Van Nostrand, Jens Lykke‐Andersen

The paper identifies quality control checkpoints in snRNA biogenesis that prevent defective snRNAs from forming aberrant spliceosomes and causing pre-mRNA splicing defects.

bioRxiv · Nov 21, 2025Molecular Biology

The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm complex assembly and 5' cap trimethylation

Tiantai Ma, Erica Xiong, Rea M. Lardelli, Jens Lykke‐Andersen

This study identifies how TOE1 selectively processes snRNAs by recognizing Sm complex assembly and 5' cap trimethylation, distinguishing them from other small non-coding RNAs.

Proceedings of the National Academy of Sciences · Jan 9, 2024Peer-reviewedMolecular Biology