Eric L. Van Nostrand

This study identifies RBFOX2 as a suppressor of oncogenic cell plasticity in Group 3 medulloblastoma by regulating alternative splicing and cytoskeletal dynamics.

This study uses APEX-seq to show that mitochondrial mRNA localization and local translation are kinetically controlled by retrograde dynein transport and translation efficiency.

The paper identifies ILF2/3 as a regulator of primate cell fate by suppressing Alu element editing, showing its role in preventing aberrant splicing and maintaining epigenetic stability.

The paper identifies quality control checkpoints in snRNA biogenesis that prevent defective snRNAs from forming aberrant spliceosomes and causing pre-mRNA splicing defects.

This study identifies QKI as a regulator of splicing fidelity during cardiogenesis by interacting with U6 snRNA to enhance splicing at weak 5' splice sites.

This study shows that 5-ethynyluridine (5EU) causes nuclear accumulation of TDP-43 and other RNA-binding proteins by altering RNA metabolism and splicing.

The paper uses chimeric eCLIP to map snoRNA-target RNA interactions, identifying novel interactions and regulatory roles in RNA biogenesis.

The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.

This study identifies SARS-CoV-2 protein-RNA interactions in infected cells, revealing roles in viral processes and potential antiviral targets.

This paper introduces chimeric eCLIP, a method to efficiently profile miRNA:mRNA interactions at scale, showing significant improvements in recovery and specificity.

The paper uses a genome-wide CRISPR/Cas9 knockout screen to identify novel transporters involved in nanoparticle uptake, finding SLC18B1 mediates polymeric micellar nanoparticle uptake.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

The paper analyzes eCLIP data for 150 RBPs in K562 and HepG2 cells, revealing binding modalities, RBP functions, and novel RNA processing mechanisms.

The paper presents a comprehensive analysis of AATF's RNA interactions, revealing its role in ribosome biogenesis through binding to pre-rRNA and mRNAs of ribosome factors.

This study identifies NIPBL's interaction with RNA and treacle in regulating pre-rRNA transcription and nucleolar organization.

The paper introduces BEAPR, a computational method to detect allele-specific binding of RNA-binding proteins, showing it outperforms existing methods and identifies disease-relevant variants.

This study identifies widespread hypo-editing in ASD brains and links RNA editing dysregulation to Fragile X syndrome through FMRP/FXR1P-ADAR interactions.

This study identifies A1CF as a regulator of plasma triglycerides through posttranscriptional control of VLDL secretion and intracellular stress pathways.