The paper identifies quality control checkpoints in snRNA biogenesis that prevent defective snRNAs from forming aberrant spliceosomes and causing pre-mRNA splicing defects.

bioRxiv · Nov 21, 2025Molecular Biology

The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm complex assembly and 5' cap trimethylation

Tiantai Ma, Erica Xiong, Rea M. Lardelli, Jens Lykke‐Andersen

This study identifies how TOE1 selectively processes snRNAs by recognizing Sm complex assembly and 5' cap trimethylation, distinguishing them from other small non-coding RNAs.

Proceedings of the National Academy of Sciences · Jan 9, 2024Peer-reviewedMolecular Biology

Assigning functionality to cysteines by base editing of cancer dependency genes

Haoxin Li, Tiantai Ma, Jarrett R. Remsberg, Sang Joon Won, Kristen E. DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin Tianmeng Zhao, Tony P. Huang, Bingwen Lu, Gabriel M. Simon, Bruno N. Melillo, Stuart L. Schreiber, Jens Lykke‐Andersen, David R. Liu, Benjamin F. Cravatt

The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.

Nature Chemical Biology · Oct 2, 2023Peer-reviewedSystems Biology