Jens Lykke‐Andersen

The paper investigates human sncRNA 3' end processing, revealing two types of adenylation that influence maturation or degradation.

The paper identifies quality control checkpoints in snRNA biogenesis that prevent defective snRNAs from forming aberrant spliceosomes and causing pre-mRNA splicing defects.

The paper identifies Angel1 as a key factor in non-stop mRNA decay by showing its role in destabilizing mRNAs lacking stop codons.

This study identifies how TOE1 selectively processes snRNAs by recognizing Sm complex assembly and 5' cap trimethylation, distinguishing them from other small non-coding RNAs.

The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.

This study shows that TTP's CIM motif enables its activity despite MK2 phosphorylation, revealing a cooperative regulation by multiple kinase pathways.

Tailer quantifies and analyzes RNA 3' end tailing from sequencing data, showing accurate and reproducible results across studies.