Moderate-term dimethyl fumarate treatment reduces pathology of dystrophic skeletal and cardiac muscle in a mouse model
Stephanie Kourakis, Cara A. Timpani, Ryan M. Bagaric, Bo Qi, Benazir Ashiana Ali, Rebecca Boyer, Guinevere Spiesberger, Nitika Kandhari, Amanda L. Peterson, Didier Debrincat, Thomas Yates, Yan Xu, Jujiao Kuang, Judy B. de Haan, Nicole Stupka, , Emma Rybalka
This study shows that moderate-term dimethyl fumarate treatment reduces dystrophic muscle pathology in a mouse model of Duchenne muscular dystrophy, with anti-inflammatory, anti-fibrotic, and anti-lipogenic effects.
bioRxiv · Jul 13, 2024 · PreprintPathology