Under pressure: Keratin 9 regulates mechanosensitive YAP1 signaling in palmoplantar epidermis
Sarah N. Steiner, Eric N. Horst, Evelyn S. Chiu, Mitre Athaiya, Craig N. Johnson, Joseph Y. Shen, Michelle L. Kerns, Joseph Kirma, Rebecca L. McCarthy, Syed F.H. Shah, Ofer Sarig, Liat Samuelov, Eli Sprecher, Edel A. O’Toole, Johann Gudjonsson, , Pierre A. Coulombe
This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.
bioRxiv · Sep 15, 2025 · PreprintDevelopmental Biology