Joseph Kirma

Disease context dictates the cellular targets of IL-17 in inflammatory skin disease

This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.

Under pressure: Keratin 9 regulates mechanosensitive YAP1 signaling in palmoplantar epidermis

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

TWEAK Signaling Drives the Transition from Psoriasis to Atopic Dermatitis-like Inflammation in Paradoxical Skin Reactions

The paper identifies TWEAK-IL-13 signaling as a driver of paradoxical skin reactions following anti-TNF, IL-17, or IL-23 therapy.

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis

This paper performs RNA-seq on skin samples from three acantholytic diseases to identify shared transcriptomic features and mechanisms of pathogenesis.