Edel A. O’Toole

Hidden immune memory niches in inflammatory skin diseases

This study creates a spatially-resolved molecular atlas of human skin and uses deep learning to identify 26 niches, revealing novel immune memory structures in inflammatory skin diseases.

A single cell and spatial genomics atlas of human skin fibroblasts in health and disease

This study creates a spatial genomics atlas of human skin fibroblasts in health and disease, identifying six major populations and three disease-specific subtypes.

Under pressure: Keratin 9 regulates mechanosensitive YAP1 signaling in palmoplantar epidermis

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

Rare disease gene association discovery from burden analysis of the 100,000 Genomes Project data

The paper identifies 88 novel rare disease-gene associations using a burden analysis framework on whole genome sequencing data from the 100,000 Genomes Project, with potential clinical impact for undiagnosed cases.

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.