Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5
Martin Benej, Katarina Benejova, Adel Fergatova, Rebecca Lisi, Kristina Travis, McKenzie Kreamer, Amy Webb, Caroline Dravillas, Rebecca Hoyd, Esin Bayralı Ülker, Aashrith Sai Thoutham, Daniel J. Spakowicz, Nicholas C. Denko
This study shows that NDUFB5 amplification in NSCLC drives tumor hypoxia and therapy resistance by increasing mitochondrial oxygen consumption.
bioRxiv · Jul 28, 2026 · PreprintCancer Biology