Author

Martin Benej

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0002-3116-445XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Daniel J. SpakowicziD· 2 shared David Paul CarboneiD· 2 shared Katarina Benejova· 2 shared Kristina Travis· 2 shared McKenzie Kreamer· 2 shared Nicholas C. DenkoiD· 2 shared Rebecca HoydiD· 2 shared Aaditya Pallerla· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Daniel J. SpakowiczORCID

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3 papers

Recent·Most cited

Targeting alpha-ketoglutarate starvation within the tumor-immune microenvironment rescues T cell effector function in cancer immunotherapy

Katarina Benejova, Kristina Travis, Deepti Mathur, No‐Joon Song, Zihai Li, Mitch A. Phelps, Elaine R. Mardis, Liza Makowski, David Paul Carbone, Dwight Hall Owen, Martin Benej

This study shows that supplementing alpha-ketoglutarate (aKG) improves T cell function and immunotherapy effectiveness in NSCLC by reversing epigenetic changes associated with T cell exhaustion.

bioRxiv · Oct 27, 2026 · PreprintCancer Biology

Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5

Martin Benej, Katarina Benejova, Adel Fergatova, Rebecca Lisi, Kristina Travis, McKenzie Kreamer, Amy Webb, Caroline Dravillas, Rebecca Hoyd, Esin Bayralı Ülker, Aashrith Sai Thoutham, Daniel J. Spakowicz, Nicholas C. Denko

This study shows that NDUFB5 amplification in NSCLC drives tumor hypoxia and therapy resistance by increasing mitochondrial oxygen consumption.

bioRxiv · Jul 28, 2026 · PreprintCancer Biology

Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival

Dennis J. Grencewicz, Alexander Loncar, Sylvain Ferrandon, McKenzie Kreamer, Dipankor Chatterjee, Yogita Mehra, Aspen Carson, Rebecca Hoyd, Shiva Jahanbakhshi, Fouad Choueiry, Matthew Z. Anderson, Martin Benej, Dustin E. Bosch, Jiangjiang Zhu, Jinghai Wu, , Daniel J. Spakowicz

This study identifies Candida albicans colonization in colorectal tumors as a factor linked to reduced survival and impaired radiation response.

bioRxiv · Sep 19, 2025 · PreprintCancer Biology