Astrocyte dysfunction distinguishes monozygotic twin C9orf72 expansion carriers discordant for amyotrophic lateral sclerosis.
Allan Christian Shaw, Iris-Stefania Pasniceanu, Rebecca Stevenson, Chloé Moutin, Gergo Erdi-Krausz, Matthew D. Parker, Matthew Wyles, Cleide Dos Santos Souza, Adrian Higginbottom, Lydia M. Castelli, Janine Kirby, Guillaume M. Hautbergue, Laura Ferraiuolo, Johnathan Cooper‐Knock, Matthew R. Livesey, Pamela J. Shaw
This study identifies distinct astrocyte states in C9orf72 expansion carriers discordant for ALS, linking epigenetic changes, stress, and functional dysfunction to disease onset.
bioRxiv · Jul 20, 2026 · PreprintNeuroscience