Matthew R. Livesey

Astrocyte dysfunction distinguishes monozygotic twin C9orf72 expansion carriers discordant for amyotrophic lateral sclerosis.

This study identifies distinct astrocyte states in C9orf72 expansion carriers discordant for ALS, linking epigenetic changes, stress, and functional dysfunction to disease onset.

Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons

The paper identifies importin 13b's role in axon diameter growth and shows its impact on conduction velocity in myelinated axons in zebrafish.

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

This study identifies 690 candidate ALS genes using a hierarchical Bayesian model, highlighting genetic convergence on the distal axon and functional significance in motor neurons.

Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish

This study shows that hypomyelination in zebrafish larvae disrupts axonal conduction and behavior, linking myelination to neural circuit function.

Safety and efficacy of C9ORF72-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis

This study shows that inhibiting SRSF1-dependent nuclear export of C9ORF72-repeat transcripts in ALS models protects neurons and identifies key RNA changes involved in disease.

Disruption to NKCC1 impairs the response of myelinating Schwann cells to neuronal activity and leads to severe peripheral nerve pathology

This study shows that disrupting NKCC1 in Schwann cells impairs their response to neuronal activity, leading to myelin defects and nerve pathology, which can be reversed by TTX treatment.

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

The paper investigates the impact of a t(1;11) translocation on white matter integrity and oligodendrocyte-myelin function using DTI and cellular models.