Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis
Rio Tsutsumi, Antoine Diez, Steffen Plunder, Ryuichi Kimura, Shinya Oki, Kaori Takizawa, Rei Nakano, Haruhiko Akiyama, Ritsuko Takada, Shinji Takada, Marco Musy, James Sharpe, Mototsugu Eiraku
The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.
bioRxiv · Aug 31, 2025 · PreprintDevelopmental Biology