Steffen Plunder

Boundary-guided cell alignment drives mouse epiblast maturation

This study identifies how tissue boundaries guide cell orientation and lumen formation during mouse epiblast maturation.

Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis

The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.

The directionality of collective cell delamination is governed by tissue architecture and cell adhesion in a Drosophila carcinoma model

This study shows that tissue architecture and cell adhesion determine the direction of collective cell delamination in Drosophila tumors.

Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion

The paper models EMT scenarios to show nuclear positioning and protrusions drive extrusion, suggesting a non-linear EMT process.

Occurrence of non-apical mitoses at the primitive streak, induced by relaxation of actomyosin and acceleration of the cell cycle, contributes to cell delamination during mouse gastrulation.

The paper shows that non-apical mitoses in the mouse gastrulation streak, driven by actomyosin relaxation and accelerated cell cycles, contribute to cell delamination, but not mesoderm identity.