Mototsugu Eiraku

Self-organized mechanochemical instabilities drive the emergence of digit tissue morphogenesis

The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.

Chromatin priming by transcription factor ELF3 confers transcriptional competence for amniotic differentiation on primed human embryonic stem cells

Reconstruction of functional olfactory sensory tissue from embryonic nasal stem cells

This study creates OE organoids from mouse embryonic stem cells that mimic the structure and molecular features of olfactory epithelium, including single OR expression and axon guidance gene patterns.

The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

This study develops a contractile organoid model from chicken embryonic hindgut to study rhythm coordination between interstitial cells of Cajal and smooth muscle cells.

Inference of gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations

This paper introduces RENGE, a method for inferring gene regulatory networks from time-series scCRISPR data, which outperforms existing methods and produces GRNs consistent with known databases.

Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

This paper introduces OptoShroom3, an optogenetic tool to control apical constriction in mammalian tissues, demonstrating its ability to induce 3D morphological changes in neural organoids.

Cell-autonomous differentiation of human primed embryonic stem cells into trophoblastic syncytia through the nascent amnion-like cell state

This study shows that blocking ACTIVIN/NODAL and FGF signals in human pESCs leads to GATA3-expressing syncytia resembling trophoblasts, revealing a cell-autonomous differentiation pathway.