Haruhiko Akiyama

This study investigates how osteocyte state transitions affect bone remodeling during early skeletal aging, finding age-dependent changes in osteocyte subpopulations and their impact on bone mass.

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

The paper develops a limb-mesenchymal organoid system and models to show that digit-like structures form through mechanochemical instabilities involving cell adhesion, chemotaxis, and convergent-extension.

The paper uses multimodal analysis to reveal cardiac neural crest lineage diversity and gene regulatory networks involved in their differentiation.

The paper shows NKX2-1 uses differential chromatin binding to resolve opposing cell fates in mouse lung progenitors, with YAP/TAZ loss altering its binding sites and leading to transcriptional changes.

The paper investigates the functional redundancy and additivity of four Lef/Tcf transcription factors in lung epithelial progenitors using genetic knockout models in mice.