Prion-like transmission of human tau strains in the mouse brain
Sofia Lövestam, Aki Shimozawa, Airi Tarutani, Reiko Ohtani, Masami Masuda‐Suzukake, Kazuko Hasegawa, Andrew Robinson, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hisaomi Suzuki, Mitsumoto Onaya, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres
This study demonstrates that tau filaments from Alzheimer's and corticobasal degeneration patients can seed the formation of structurally identical mouse tau filaments, supporting the prion-like transmission hypothesis.
Nature · Sep 30, 2026Peer-reviewedNeuroscience