Author

Yuko Saito

Tokyo Metropolitan Institute of GerontologyORCID 0000-0002-9974-8638Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yuko Saito1 paper · Tokyo Metropolitan Institute of Gerontology

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Shigeo MurayamaiD· 2 shared Aika Akahori· 1 shared Airi TarutaniiD· 1 shared Aki ShimozawaiD· 1 shared Akinori MiyashitaiD· 1 shared Andrew RobinsoniD· 1 shared Hayato Etani· 1 shared Hideyuki OkanoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Shigeo MurayamaORCID

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2 papers

Recent·Most cited

Prion-like transmission of human tau strains in the mouse brain

Sofia Lövestam, Aki Shimozawa, Airi Tarutani, Reiko Ohtani, Masami Masuda‐Suzukake, Kazuko Hasegawa, Andrew Robinson, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hisaomi Suzuki, Mitsumoto Onaya, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

This study demonstrates that tau filaments from Alzheimer's and corticobasal degeneration patients can seed the formation of structurally identical mouse tau filaments, supporting the prion-like transmission hypothesis.

Nature · Sep 30, 2026Peer-reviewedNeuroscience

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi, Yusuke Amiya, Aika Akahori, Hirotaka Watanabe, Iki Sonn, Hideyuki Okano, Norikazu Hara, Mai Hasegawa, Akinori Miyashita, Masataka Kikuchi, Takeshi Ikeuchi, Maho Morishima, , Taisuke Tomita

This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.

Alzheimer s Research & Therapy · Nov 20, 2025Peer-reviewedNeuroscience