Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic mice.
Soumitra Ghosh, Han Lin, Sarah Chu, Hai Ngu, Nanzhi Zang, Renee Raman, Kimberly L. Stark, Oded Foreman, Somaye Sadat Hashemifar, Amy E. Easton, Baris Bingol, William J. Meilandt
This study develops a mouse model of Parkinson's disease by injecting alpha-synuclein pre-formed fibrils, leading to bilateral dopaminergic neurodegeneration and BBB compromise.
Discover Neuroscience · Aug 27, 2026Peer-reviewedNeuroscience