Author

William J. Meilandt

GenentechORCID 0000-0002-8672-8769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Amy E. EastoniD· 2 shared Albert LiuiD· 1 shared Alexander MunkiD· 1 shared Alvin GogineniiD· 1 shared Anne BieveriD· 1 shared Anubha MahajaniD· 1 shared Baris BingoliD· 1 shared Borislav DejanoviciD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Amy E. EastonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic mice.

Soumitra Ghosh, Han Lin, Sarah Chu, Hai Ngu, Nanzhi Zang, Renee Raman, Kimberly L. Stark, Oded Foreman, Somaye Sadat Hashemifar, Amy E. Easton, Baris Bingol, William J. Meilandt

This study develops a mouse model of Parkinson's disease by injecting alpha-synuclein pre-formed fibrils, leading to bilateral dopaminergic neurodegeneration and BBB compromise.

Discover Neuroscience · Aug 27, 2026Peer-reviewedNeuroscience

Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer's disease

Yuanyuan Wang, Tiffany Z. Wu, Alvin Gogineni, Ming‐Chi Tsai, Lukasz Jan Kielpinski, Anubha Mahajan, Shristi Pandey, Luis F. Schachner, John C. Tran, Cong Wu, Stephen P. Schauer, Anne Biever, Sidsel Boesen, Meiling Li, Alexander Munk, , Jesse E. Hanson

This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.

bioRxiv · Aug 23, 2024 · PreprintNeuroscience

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer's disease model

Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt, Borislav Dejanovic, Yiming Zhou, Christopher J. Bohlen, Seung-Hye Lee, Jingyi Ren, Albert Liu, Zefang Tang, Hao Sheng, Jia Liu B, Morgan Sheng, Xiao Wang

The paper introduces STARmap PLUS to map single-cell transcriptional states and disease markers in AD mouse models, revealing spatial relationships between cell types and pathological features.

Nature Neuroscience · Feb 2, 2023Peer-reviewedGenomics