Takahiro Itamiya

Accurate, sensitive, and efficient chromatin accessibility quantification at target loci using UNIChro-seq.

The paper introduces UNIChro-seq, a method for quantifying chromatin accessibility at target loci, and demonstrates its application in analyzing disease risk alleles and genome-edited variants.

CATaN maps gene regulatory programs that shape genetic risk across complex diseases

CATaN integrates TF-GRNs and transcriptomes to identify genetic risk components across complex diseases, finding 588 significant CC components enriched for SNP heritability.

An APOC1+ inflammatory CAF-like state drives a senescent, treatment-resistant niche in rheumatoid arthritis

The paper identifies a treatment-resistant fibroblast state in RA synovitis that drives chronic inflammation through senescence-associated mechanisms and highlights therapeutic targets beyond cytokine inhibition.

Cell-type-specific transcriptome architecture underlying the establishment and exacerbation of systemic lupus erythematosus

This study identifies cell-type-specific transcriptomic signatures associated with SLE disease establishment and exacerbation, highlighting their clinical relevance and potential limitations in capturing genetic risk factors.