Live-Cell Covalent Profiling Reveals Principles of RNA-Small Molecule Recognition across the Human Transcriptome
Yuquan Tong, Amirhossein Taghavi, Xiaoxuan Su, Xueyi Yang, Warren B. Rouse, Sandra Kovachka, Jessica L. Childs‐Disney, Ryuichi Sekioka, Rey Zavala, Yanjun Li, Walter N. Moss, Matthew David Disney
The paper develops a live-cell method to identify RNA-small molecule interactions and uses it to design selective RNA degraders.
bioRxiv · Nov 5, 2025 · PreprintBiochemistry