Xueyi Yang

This paper develops a programmable platform to recruit RNA-binding proteins using small molecules, enabling RNA destabilization, and demonstrates its application to MAPT pre-mRNA.

This study shows that degrading the miR-21 precursor with TGP-21-RiboTAC reduces pathogenic pathways in fibrosis models by reactivating tumor suppressor genes.

This paper introduces epoxide- and aziridine-2-carboxamide electrophiles that covalently target RNA with stereoselectivity, demonstrating their application to RNA targets like r(CUG)exp repeats and FMN riboswitches.

The paper identifies bioactive ligands for the toxic r(G4C2)exp RNA using DNA-encoded libraries combined with docking and SAR analysis.

The paper develops a live-cell method to identify RNA-small molecule interactions and uses it to design selective RNA degraders.