Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation
Ching Zhu, Takako Makita, Emilio Y. Lucero, Arun Jyothidasan, Rhea Patel, Jessica Wang, Yang Cao, Howard A. Rockman, Kalyanam Shivkumar
This study shows that loss of plexin-mediated cardiac innervation leads to adrenergic hypersensitivity and ventricular arrhythmias in mice, with human PLXNA4 variants linked to arrhythmias.
JACC. Clinical electrophysiology · Oct 4, 2025Peer-reviewedPhysiology