Author

Arun Jyothidasan

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David K. CrossmaniD· 2 shared Howard A. RockmaniD· 2 shared Aijun QiaoiD· 1 shared Alem W. KahsaiiD· 1 shared Ali MasoudiiD· 1 shared Angus Li· 1 shared Anil Kumar ChallaiD· 1 shared Brain Dally· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenomics

David K. CrossmanORCID

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Author profile →

4 papers

Recent·Most cited

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

Samuel Liu, Peng Xiao, Matthias Elgeti, Eve J. Fine, E Lucero, Mikkel Vestergaard, Junyan Wang, Arun Jyothidasan, Angus Li, Changxiu Qu, Eva Olsen, Georgios Mazis, Josephine K. Madsen, Carl‐Mikael Suomivuori, Ji Hee Kim, , Robert J. Lefkowitz

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Adrenergic Hypersensitivity Drives Ventricular Arrhythmias Following Loss of Plexin-Mediated Cardiac Innervation

Ching Zhu, Takako Makita, Emilio Y. Lucero, Arun Jyothidasan, Rhea Patel, Jessica Wang, Yang Cao, Howard A. Rockman, Kalyanam Shivkumar

This study shows that loss of plexin-mediated cardiac innervation leads to adrenergic hypersensitivity and ventricular arrhythmias in mice, with human PLXNA4 variants linked to arrhythmias.

JACC. Clinical electrophysiology · Oct 4, 2025Peer-reviewedPhysiology

Transcriptional regulation of structural and functional adaptations in a developing adulthood myocardium

Sini Sunny, Anil Kumar Challa, Aijun Qiao, Arun Jyothidasan, Prasanna Krishnamurthy, Muralidharan Thoddi Ramamurthy, David K. Crossman, Steven M. Pogwizd, Senthilkumar Cinghu, Namakkal Soorappan Rajasekaran

The paper investigates transcriptional changes in mouse myocardium during post-natal to adult transition, finding significant gene expression shifts and structural-functional adaptations.

Cardiology and Cardiovascular Medicine · Jan 1, 2021Peer-reviewedGenomics

Basal Role for Nrf2-transgne on transcriptional (mRNA/miRNA) regulation in the mouse myocardium

Arun Jyothidasan, Gobinath Shanmugam, John H. Zhang, Brain Dally, David K. Crossman, Rajasekaran Namakkal Soorappan

This study investigates the basal role of excess Nrf2 in regulating mRNA and miRNA interactions in the mouse myocardium using transgenic mice and high-throughput sequencing.

bioRxiv · Dec 9, 2018 · PreprintMolecular Biology