Author
Duke UniversityORCID 0000-0003-2921-1584Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Samuel Liu, Peng Xiao, Matthias Elgeti…·Robert J. Lefkowitz
The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.
Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon…·Robert J. Lefkowitz
This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.
Ching Zhu, Takako Makita, Emilio Y. Lucero…·Kalyanam Shivkumar
This study shows that loss of plexin-mediated cardiac innervation leads to adrenergic hypersensitivity and ventricular arrhythmias in mice, with human PLXNA4 variants linked to arrhythmias.