Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associations
Noor E. Shakfa, Ferris Nowlan, Sibyl Drissler, Tiak Ju Tan, Elizabeth Sunnucks, E. Chen, Cassandra J. Wong, Brendon Seale, Zhen‐Yuan Lin, Michelle Chan‐Seng‐Yue, Amy Xin Wei Zhang, Sabiq Chaudhary, Chengxin Yu, Golnaz Abazari, Michael J. Geuenich, , Hartland Warren Jackson
This study integrates spatial proteomics and genomics in PDAC to identify tumour-immune-stroma interactions and their genomic associations, showing multi-omics models improve patient survival prediction.
bioRxiv · Aug 15, 2025 · PreprintCancer Biology