Anne‐Claude Gingras

The paper identifies DDIAS as a DNA-binding effector of the CIP2A-TOPBP1 complex that suppresses single-stranded DNA during mitosis, protecting genome integrity and interacting genetically with DNA polymerase.

The paper improves library construction for low-input proteomics by using reference samples, showing significant performance gains in both OpenSWATH and DIA-NN workflows.

This study identifies PRMT1 as a replisome-associated methyltransferase that suppresses ssDNA gap formation by methylating MCM4, thereby maintaining fork integrity during DNA replication.

This study maps spatiotemporal changes in cytoskeletal and junctional protein interactions during somatic cell reprogramming using time-resolved proximity proteomics.

This study identifies SCM-1/SCAMP as a key factor maintaining microdomain boundaries in the endosomal system, ensuring proper cargo sorting and preventing microdomain overlap.

This study demonstrates that activating CBL ubiquitin ligase via engineered mutants or small molecules can downregulate tyrosine kinase signaling by enhancing substrate ubiquitination and reducing downstream signaling.

This study investigates the role of Mob4, a STRIPAK complex component, in zebrafish vascular development and stability, revealing defects similar to cerebral cavernous malformation.

The paper develops GENBAIT, a genetic algorithm-based tool to optimize bait selection for BioID experiments, reducing bait numbers while maintaining dataset coverage and structure.

This study shows that the PAN2-PAN3 deadenylation complex can be recruited to specific mRNAs via RNA adaptors, adding to the specificity of mRNA degradation.

This study investigates how BLBS-causing H3.3 mutations affect H3K36 methylation and effector protein binding, revealing molecular similarities across mutations.

This study benchmarks ten proximity ligases across cellular compartments and time windows, finding variations in activity, background, and spatial specificity, with ultraID showing the best balance.

This study integrates spatial proteomics and genomics in PDAC to identify tumour-immune-stroma interactions and their genomic associations, showing multi-omics models improve patient survival prediction.

This study shows AMPK regulates clathrin-mediated endocytosis by controlling Dab2 and Arf6 to selectively internalize β1-integrin.

The paper investigates how multiple FGFR1 mutations affect tumorigenic mechanisms in glioneuronal tumors by analyzing their interactomes and functional impacts.

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

The paper identifies RAD54L2 as a regulator of recombination by showing its interaction with the BTRR complex and its role in suppressing sister chromatid exchanges.

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.

The paper shows that GATOR1 regulates GSK3β nuclear localization in response to amino acids, independent of mTORC1, and that this process supports cell survival under metabolic stress.

The paper investigates the evolution of chromosome 4p loss in basal breast cancer, identifying C4orf19 as a novel gene that suppresses proliferation and is part of a kinase module.

The paper introduces ecTurboID, a method to profile extracellular protein interactions, identifying LDLR as a new EGF-dependent EGFR partner.

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.

The paper compares noDE and DDA/DIA methods for protein-protein interaction detection, finding noDE provides better sensitivity and identifies more high confident interactors.

The paper identifies and functionally characterizes transcriptional activators in human cells, revealing novel activators involved in tumor fusion events.

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

Profiling 192 subcellular markers by proximity-dependent biotinylation (BioID) in human HEK 293 cells maps 4,145 proteins across 32 compartments via 35,902 interactions, available with analysis tools at humancellmap.org.

The paper develops and benchmarks in vivo TurboID and miniTurbo labeling in zebrafish embryos for proximity-dependent biotinylation, enabling protein discovery in living vertebrates.