Studies on the mechanism of general anesthesia
Mahmud Arif Pavel, E. Nicholas Petersen, Hao Wang, Richard A. Lerner, Scott B. Hansen
This study identifies lipid rafts and phospholipase D2 (PLD2) as targets of inhaled anesthetics, showing they disrupt rafts to activate TREK-1 channels and induce loss of consciousness.
bioRxiv · Jun 19, 2019 · PreprintNeuroscience