Scott B. Hansen

This study shows GABA induces GABAAR translocation to PIP2 clusters in neurons, with astrocytic cholesterol influencing this process and affecting receptor function.

The paper shows mechanical force activates TREK-1 channels via PLD2 and lipid clustering, leading to second messenger signaling and ion flow.

This study shows that astrocyte-derived cholesterol, released via apoE, promotes neuroinflammation by enhancing inflammatory signaling in immune cells.

The paper shows astrocyte-derived cholesterol regulates amyloid precursor protein trafficking to lipid rafts, affecting Aβ and sAPP production in neurons, and disrupting cholesterol synthesis reduces amyloid pathology in mice.

This study identifies lipid rafts and phospholipase D2 (PLD2) as targets of inhaled anesthetics, showing they disrupt rafts to activate TREK-1 channels and induce loss of consciousness.